THYROID FUNCTION OF CHILDREN ON CARBAMAZEPINE, PRIMIDONE, PHENOBARBITAL, AND VALPROIC ACID |
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| Language |
English |
| Corres.Author |
K. L. Narendra |
| Email |
Narendra@gmail.com |
| Accepted Date |
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| File size |
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| No of Downloads |
260 |
| Published by |
IJCPCR |
| Full Text |
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| There is a decrease in free thyroxin (FT4) and T4 concentrations with Carbamazepine (CBZ) therapy, although TSH levels remained unchanged [1]. Multiple studies with the aim of evaluating serum thyroid hormone regulation in children undergoing long-term Carbamazepine therapy were proposed as a result of this research [2]. CBZ can trigger subclinical hypothyroidism. Both Phenytoin (PHT) patients experience a significant decrease in thyroid hormone serum levels [3,4]. There are only a few studies on the correlation between barbiturates and thyroid hormone levels. A total of 55 children with epilepsy were randomly assigned to one of four groups: phenobarbital, PRM, CBZ, or VPA, depending on whether they had generalized or partial epilepsy. Phenobarbital was given to twenty-nine cases (75.9% male and 24.1 percent female, mean age: 38 28.75 months). There was no substantial difference in serum T3, T4, T3RU, and TSH levels in Phenobarbital patients before and 3 months after prescribing (P>0.05). Their ages were slightly lower than those of the CBZ and VPA classes. Primidone was given to twenty-eight patients (64.3 percent male and 35.7 percent female, mean age 35.37 31.85 months). They were slightly younger than the CBZ and VPA classes (p0.05), but there were no substantial variations in serum T3, T4, T3Ru, and TSH levels before and after therapy (p>0.05).ddd |
