| Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are mucocutaneous cell-mediated hypersensitivity reactions that are relatively infrequent, but potentially fatal, and are frequently produced by drugs. Fever, malaise, facial puffiness, mucous membrane eruptions, skin lesions, vomiting, and skin eruptions are all symptoms of SJS and TEN. SJS and TEN have incidences of 0.4-1.2 per million and 1.2-6 per million person-years, respectively. A 28-year-old female patient has a history of left-sided pain. Anti-tubercular medication was started for the lateral pleural effusion. (ATT) [Isoniazid, rifampicin, pyrazinamide, and pyrazinamide tablet (presentation:] for a month at a local hospital. Even though the Patient was non-compliant with treatments and acquired ATT as a result. We present a rare instance of phenytoin-induced SJS that was made worse by cefepime treatment. In our research of the literature, we couldn't discover any examples of such unusual reactions. The interaction of nucleophilic groups with lysine amino groups of proteins to create cephalosporin proteins could be a plausible cause of SJS aggravation. The mechanism of this pharmacological interaction, however, is unknown at this time. Cefepime should therefore be used with caution in patients who have previously experienced drug-induced SJS.ddd |
