| Oral administration is likely the least intrusive method of administering drugs; it is a method that the patient knows and
accepts, as well as one that the patient can administer. For the producer, solid oral dosage forms have numerous
advantages: they are frequently the most stable forms of drug, they are compact, and their appearance may be changed to
increase brand identification. Telbivudine was selected since it is a soluble medicine at the pH of the gut. Telbivudine is a
key component of HIV treatment. The goal of this work was to create matrix porous Telbivudine tablets. The
hydroxypropyl methyl cellulose and eudragit polymers used were of various grades. The direct compression technique was used to make all of the formulations using a 6mm punch on an 8-station rotary tablet punching machine. All of the
formulations' combined flow properties, including angle of repose, bulk density, and tapped density, were adequate. The
LTF3 formulation was shown to be the most optimum of all the formulations, with a percent drug release of 98.65 percent in 10 hours. At a dose of 20 mg, HPMC K15M is incorporated in the LTF3 formulationddd |
