| Staphylococcus aureus is typically the pathogen responsible for infections of the bloodstream that are brought on by the use
of catheters (CRBSI). In order to treat the infection, it is typically necessary to remove the implanted medical device. This
is due to the fact that the bacteria are capable of forming multilayered biofilms on the material that has been implanted. In
order for this biofilm to form, the bacterium must adhere to the artificial surface. The biofilm will not form until this step is
complete. This is an essential part of the process. This study, in particular, observed how Staphylococcus aureus adheres to
central venous catheters by using single-cell force spectroscopy (SCFS). In SCFS experiments with S. aureus, maximum
adhesion forces were found to be comparable on three different types of CVCs (between 2 and 7 nN). This was the case
when comparing the adhesion forces. These values dropped by a sizeable amount after the surfaces of the CVCs were
subjected to a preincubation Human serum albumin or blood plasma. When fresh CVCs withdrawn from patients were
examined for S. aureus cells who did not have CRBSI, similar reductions were observed in the number of bacterial
colonies. According to these findings, once the central venous catheter (CVC) has been inserted into the vein, the S. aureus
is significantly, and negatively, affected by CVC tubing. Blood plasma or serum albumin can be used to precondition CVC
tubes, it may be possible to reduce the chances of Staphylococcus aureus contaminating the CVC during insertionddd |
