| Acidosis, coagulopathy, and hypothermia are lethal triads that can exacerbate exsanguination from hepatic trauma.
Hypothermic coagulopathic liver damage model with modified chitosan dressings was tested. As a result of hypothermic
coagulopathy, subject swine underwent standardized grade V liver injuries. It was compared with a standard packing with a
modified chitosan dressing. Blood loss and pre-treatment temperature were similar between groups. The modified chitosan
group displayed a significant reduction in post-treatment blood loss and an increase in resuscitation mean arterial pressure
(P < 0.0001 and P < 0.018, respectively). Compared to the control group, the modified chitosan group had a significantly
lower mean fluid resuscitative volume (P <0.0056). As compared to standard packing, modified chitosan achieved
haemostasis on average in 5.2 minutes. Half of treatment animals survived an hour after injury compared to all control
animals. Injuries to the liver can be treated using modified chitosan dressings in a simple and rapid manner.ddd |
