| An empirical study found that infants received Inhaled nitric oxide have significant oxygenation issues due to pH. During 98
hours of life, 142 infants receiving Inhaled nitric oxide were charted for demographic details, ventilation settings, arterial
blood gases (ABGs), and interventions. It was noted that there was a need for ECMO and that the patient would survive until
discharge. A mean blood pressure measurement was conducted, as well as a mean airway pressure measurement. Our
primary outcome of interest was the arterial/alveolar (a/A) ratio in order to assess the clinical outcomes. Fisher's exact test
and simple linear regression analyses were used in the analysis, along with the multiple linear regression analysis. In order to
define pH responsiveness, the correlation coefficient (CC) had to exceed 0.40 with a P value of 0.05. The mean gestational
age and birth weight were 35.5 weeks and 3700 grams, respectively. PPHN was clinically diagnosed in all patients. The a/A
ratio was not correlated with the MAP or MBP in 82 out of 142 infants. six responders had critical pH levels greater than
7.41. Among 26 patients who needed ECMO, eight showed some signs of responsiveness. It was necessary for six
responders to receive ECMO. This small study suggested that the inability to respond to Inhaled nitric oxide could be a result
of inability or failure to optimize pH levels. It is not recommended to maintain pH levels greater than 7.5 while using
hyperventilation to do thisddd |
