| Prevalence of chronic kidney disease is increasing and became one of the biggest health problem around the
globe. Researchers in western countries had done researches on eGFR to diagnose the kidney disease at the initial stages
and to prevent the progression of the disease. Indian population eGFR values varies from the western population eGFR. To
evaluate the eGFR calculated using MDRD formula in different age groups of healthy Indian individuals and observe the
association between GFR and age, gender in healthy Indian population. A total of 410 healthy individuals of age from 31 to
70 years were selected and divided into four groups accordingly to the age. Group I – 31 to 40 years, Group II – 41 to 50
years, Group III – 51 to 60 years and Group IV – 61 to 70 years. Serum creatinine levels was estimated by Jaffe’s method.
eGFR was assessed by MDRD formula. We observed a statistical significances between both the genders in the group I (p
< 0.001), group II (p < 0.001), group III (p < 0.05) and group IV (p < 0.001). Females mean value of eGFR is slightly
lower than the eGFR mean value of males. Among 410 healthy individuals age from 31 to 70 years, majority of the
individuals have eGFR value less than 90 ml/min in both genders. Elderly individuals normally had low eGFR compared to
adult individuals in many studies. Low eGFR value in elderly people should not be misdiagnosed as kidney disease. eGFR
calculated using MDRD formula highlights the importances in diagnosing kidney disease except in elderly individualsddd |
