| Depression is a widespread mental health concern with multifaceted etiological factors, including potential hormonal and
immunological alterations. This cross-sectional study aims to investigate the relationships between depression and markers
of hormonal and immunological status in adults. A total of 146 adults, aged 18 to 65, were recruited for this study,
comprising 73 individuals diagnosed with depression and 73 age-matched healthy controls. Hormonal assessments
included thyroid-stimulating hormone (TSH), and prolactin, while immunological parameters encompassed C-reactive
protein (CRP) and Fasting blood glucose. The severity of depression was evaluated using standardized psychometric tools.
Preliminary findings reveal significant alterations in TSH and prolactin were observed in the depressed group compared to
controls (p<0.01), suggesting perturbations in thyroid function and reproductive hormones. Immunological assessments
demonstrated elevated CRP levels in depressed individuals (p<0.001), indicative of an inflammatory response associated
with depression. This cross-sectional study provides initial insights into the hormonal and immunological alterations
associated with depression in adults. The observed dysregulations in TSH, prolactin, FBS and CRP emphasize the intricate
interplay between the endocrine and immune systems in depressive disorders. Further exploration of these associations
may contribute to a better understanding of the pathophysiological mechanisms underlying depression and facilitate the
development of targeted therapeutic interventions.ddd |
