Osteoarthritis (OA) is a prevalent musculoskeletal disorder characterized by articular cartilage degeneration, subchondral
bone changes, and joint inflammation. Among the multifaceted factors influencing OA pathogenesis, Bone Marrow
Lesions (BMLs) have become a focal point of investigation due to their association with pain, cartilage loss, and disease
progression. Recent research has identified a potential connection between knee joint morphological parameters,
particularly the Proximal Tibial Slope (PTS), and the development of BMLs. The medial aspect of the proximal tibia, in
particular, has been implicated in biomechanical stress on the knee's medial compartment. This study aims to elucidate the
association between BMLs and the Greater Medial Proximal Tibial Slope (MPTS) in middle-aged women. The focus on
middle-aged women stems from the critical juncture in life when early signs of osteoarthritis often manifest. Moreover, as
women are disproportionately affected by OA, they represent a crucial demographic for understanding disease dynamics.
This investigation seeks to unravel the biomechanical factors contributing to BML development, particularly in the context
of the MPTS. The study obtained ethical approval and involved 365 participants over a two-year period (June 2019-June
2020) at the Sree Balaji Medical College and Hospital,Chrompet, Chennai.Orthopaedic Ward. Inclusion criteria comprised
patients aged 45-60 with bone marrow lesions, and female patients without radiographic abnormalities, while exclusion
criteria included radiographic abnormalities, rheumatoid arthritis, incomplete data, and a history of knee injury. Lifestyle
habits, including drinking, smoking, and exercise frequency, were assessed through a questionnaire. General health
examinations and prophylactic interventions aimed to improve average life expectancy were conducted. The study employs
advanced imaging techniques and rigorous statistical analyses to comprehensively explore the relationship between BMLs
and the Greater Medial Proximal Tibial Slope in middle-aged women. Anticipated findings hold promise for informing
early detection and targeted interventions in osteoarthritis, contributing to enhanced patient outcomes and a deeper
understanding of the intricate interplay between knee morphology and joint healthddd |