| Postoperative cognitive dysfunction is commonly encountered after major surgical operations. This study was conducted to
evaluate the effect of dexmedetomidine on neurocognitive dysfunction and postoperative recovery after total laryngectomy
in the elderly population. Postoperative cognitive dysfunction is one of the most common complications affecting the
central nervous system after general anaesthesia and surgery especially in elderly patients. It’s characterized by short-term
cognitive decline and includes memory, mood, confusion, and sleep disorders. Its medical manifestations include cognitive
disorder, personality exchange and memory loss, intellectual problems and social impairment. Starting with demographic
data, the mean age of the included cases was 69.98 and 70.02 years in the Dex and control groups, respectively. Males
represented the majority of the included cases, as they formed 100 and 98.9% of cases in the same groups, respectively.
Body mass index (BMI) had mean values of 28.11 and 27.43kg/m2 in the two groups, respectively. Dexmedetomidine
admin is related with a considerable development of cognitive function after surgery in the elderly inhabitants. It is linked
with a better analgesic and sedative profile and decreased neurological inflammatory markers (S100B). Conversely, we
should closely monitored for side effects like bradycardia and hypotension in patients. Dexmedetomidine administration is
associated with a significant improvement of cognitive function after surgery in the elderly population. It is associated with
a better analgesic and sedative profile along with decreased neurological inflammatory markers. However, the patient must
be closely monitored for side effects like bradycardia and hypotension.ddd |
