| Near infrared autofluorescence (NIA) and optical coherence tomography (OCT) have emerged as valuable imaging
modalities for assessing central serous chorioretinopathy (CSC), exhibiting patterns similar to fluorescein angiography
(FA). In this study, spectral-domain ophthalmologic examinations were conducted on patients with a minimum history of 7
months of CSC. Seventeen eyes from thirteen patients were included, presenting with characteristic features such as
pigment mottling and mottled hyperfluorescence on FA. NIA images revealed localized areas of hypoNIA corresponding
to leaky points observed on FA, alongside hyperNIA resembling findings on fundus autofluorescence (FAF). OCT scans
demonstrated detachment of the pigment epithelium at these hypoNIA spots. Additionally, during FAF, increased
fluorophore presence was detected in areas of retinal detachment, potentially indicating lipofuscin accumulation in retinal
pigment epithelium (RPE) or debris within subretinal fluid. Furthermore, the quantity of NIA in choroidal melanin
correlated with areas of both increasing and decreasing NIA, suggesting underlying RPE and choroidal involvement. The
presence of pigment epithelial detachments (PEDs) in hypoNIA areas further supports the hypothesis of CSC as a primary
choroidal disease. These findings highlight the utility of NIA and OCT in elucidating the pathogenesis and characteristics
of CSC, offering insights into its underlying mechanismsddd |
