| This study aimed to assess the impact of proton pump inhibitors (PPIs) on enzyme immunoassay tests for Helicobacter
pylori developed by TestMate. A total of 56 patients underwent stool antigen tests and breath urea tests before and after
receiving PPI therapy. Before and after PPI treatment, the stool antigen test showed a sensitivity, specificity, and agreement
of 96.2%, 72.4%, and 90.3%, respectively, across all 56 patients. Following PPI therapy, breath urea test (UBT) values
decreased from 24.98% to 17.19% in 30 patients treated for 4 weeks, indicating a reduction of 4.75%. Moreover, the stool
antigen optical density ratios remained relatively consistent before (2.16 ± 0.21) and after (2.17 ± 0.254) treatment, with
similar results observed in patients treated for over 4 weeks (2.00 ± 0.27 before treatment and 0.69 ± 0.29 after treatment).
Notably, even in the presence of PPI administration, stool antigen testing demonstrated sensitivity comparable to UBT,
underscoring its utility and reliability as a diagnostic tool for Helicobacter pylori infection across all casesddd |
