| A more than 50-year history of use in medicine has been MPS, a mucopolysaccharide polysulphate. It is used to treat
inflammation and thrombosis. Hydrogen bonds between its molecules and adjacent water molecules allow it to effectively
hydrate surrounding tissues. Furthermore, it increases the skin's viscoelasticity and water-binding capacity by stimulating
endogenous hyaluronate synthesis. Studying the effectiveness of 0.1% MPS in hydration and elasticity of human skin. In
the first part of this study, 120 female volunteers with dry skin, as defined by Corneometer, aged 31–50 years were
randomized double-blind placebo-controlled. MPS 0.1% or a vehicle control were administered to the volunteers. For a
period of four weeks, each subject applied 1 g of cream twice daily to their face. We recruited 40 female volunteers
between the ages of 31 and 50 who had dry skin according to Corneometer. Identical forearms were randomly selected for
the application of MPS cream containing 0.1%. Skin hydration measurements were taken at baseline, immediately after
application, and every 1 hour thereafter. This improvement was maintained for 10 hours. Comparing MPS with vehicle
control, women with dry skin experienced an improvement in skin hydration but not in skin elasticity. After a single
application of MPS, skin hydration remained improved for at least 10 hours.ddd |
