Ulcers are an open sore of the skin or mucus membrane characterized by sloughing of inflamed dead tissue. Ulcers are
lesions on the surface of the skin or a mucous membrane characterized by a superficial loss of tissue. Ulcers are most
common on the skin of the lower extremities and in the gastrointestinal tract, although they may be encountered at almost
any site. There are many types of ulcer such as mouth ulcer, esophagus ulcer, peptic ulcer, and genital ulcer .Of this peptic
ulcer is seen among many people. Pylorus ligation has been reported to causes severe hemorrhagic necrosis .Results of
Histopathological studies have shown that pre-treatment with the AEEA (100 mg/kg/p.o. and 200 mg/kg/p.o.) reduced
pylorus ligation-induced hemorrhagic necrosis in rats and also reduced sub mucosal oedema and leukocyte infiltration.
Histopathology of reserpine administered stomach showed severe mucosal injury along with oedema in sub mucosal layer.
Pre-treatment with AEEA (100 mg/kg/p.o. and 200 mg/kg/ p.o.) reduced the effects and maintained the mucosal integrity
in a dose dependent manner. It may be concluded that AEEA (50 mg/kg/p.o. and 100 mg/kg/ p.o.) exerts gastro protective
and antioxidant effect as it reduces the oxidative stress and consequently improves the integrity of gastric mucosa and
enhances the generation of nitric oxide and mucus in experimentally-induced gastric ulcers. It was also concluded that
AEEA at a dose of 200 mg/kg was more potent than 100 mg/kg.ddd |