| The anterior sclera plays a crucial role in maintaining ocular integrity, and its thickness (AST) is influenced
by axial length (AL), age, and refractive status. Despite its importance, limited studies have explored quadrant-specific
variations in AST and their correlation with these factors. This study aims to investigate the relationships between AL, age,
and AST across different refractive groups. Methods: A convenience sample of 125 participants aged 20–35 years was
recruited and categorized into three groups: emmetropia (n = 39), low-to-moderate myopia (n = 43), and high myopia (n =
43). Comprehensive ocular examinations included measurements of AL, spherical equivalent (SE), and AST in nasal,
temporal, upper, and lower quadrants using optical coherence tomography. Data were analyzed using correlation analysis,
ANOVA, and multiple linear regression to determine associations. Results: AL negatively correlated with AST in all
quadrants, with the strongest correlation observed in the nasal quadrant (r = ?0.557, p < 0.001). Age showed a positive
correlation with AST in most quadrants, except the lower side, with the strongest association in the upper quadrant (r =
0.645, p < 0.001). Multiple linear regression revealed that AL and age collectively explained 54.3% of the variance in AST
(R² = 0.543, p < 0.001). These findings highlight distinct patterns of scleral remodeling associated with axial elongation
and aging. Conclusion: The study demonstrates significant correlations between AL, age, and AST, with pronounced
variations across quadrants. AL contributes to scleral thinning in myopia, while aging leads to localized thickening in
certain quadrants. These findings underscore the need for targeted interventions to address scleral remodeling in myopic
and aging eyes.ddd |
